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 HBV mutation literature information.


  Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
 PMID: 29287068       2017       PloS one
Result: Of these 86 sites, the following 19 were associated with postoperative survival at statistically significant levels (P<0.05) in HCC tissue based on the log-rank test with the Kaplan-Meier method (Table 3): nucleotides 2525 (Asp73Glu), 2733 (Lys143Gln), 2738, 2768, 2946 (Val210Ile), 3063, 3066 (Pro249Ser), 3109 (Thr268Ser), 31 (Ser314Pro), 529 (Asp480Asn), 735, 939, 1078 (Ser663Ala), 1137, 1383, 1461, 1485, 1544 (Val818Asp or Val818Ala); and 1613 (Arg841Lys).
Table: R841K


  A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
 PMID: 23852705       2013       Journal of medical virology
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv



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