literature

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Introduction: In a study conducted in the Korean population, the five HBcAg mutations P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop were significantly more frequent in subjects with chronic hepatitis and cirrhosis.

Discussion: However, in spite of their prevalence, our data showed that E80Q/D, E113D/Q, S181P/R and Q182K/*Stop variations were not statistically significantly different among the groups.

Discussion: There were some variations such as E77Q,

PMID: 33803998 2021 Microorganisms

Abstract: We also found that there are a total of 19 signature single nucleotide polymorphisms (SNPs), of which 2 and 17 nonsynonymous mutation types were specific to rt269L and rt269I, respectively: Of these, most are HBeAg negative infections (preC-W28*, X-V5M and V131I), lowered HBV DNA or virion production (C-I97F/L, rtM204I/V) or preexisting nucleot(s)ide analog resistance (NAr) (rtN139K/H, rtM204I/V and

The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.

PMID: 30406036 2018 Frontiers in cellular and infection microbiology

Introduction: Furthermore, five HBcAg mutations identified in a Korean population, P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop, were shown to be significantly enriched in HCC patients compared with patients at earlier disease stages, including those with cirrhosis and chronic hepatitis (Kim et al.,).

Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.

PMID: 28373061 2017 Virus research

Result: Conversely, the Q182* nonsense mutation, which shortened core protein by just two residues without impairing its function in supporting genome replication, was present in 8 HCC clones but only 1 non-HCC clone.

Discussion: These include E180G, S181P, Q182K, and Q182* to remove the last 2 residues (Q182 and C183) of core protein.

Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.

PMID: 23071796 2012 PloS one

Abstract: Six (preC-W28*, C-P5H/L/T, C-E83D, C-I97F/L, C-L100I and C-Q182K/*) and seven types (preC-W28*, preC-G29D, C-D32N/H, C-E43K, C-P50A/H/Y, C-

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