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 HBV mutation literature information.


  Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
 PMID: 19327810       2009       Virology
Result: This finding, together with the results of the mapping experiments, establishes that amino acid substitutions at the N-terminus of the 2A core protein (A36Tor G63V) reduce the stringency of virion secretion, whereas amino acid changes at the C-terminus of the 4B core protein (T147A, R151C, D153G, or Q179K) enhance genome maturity of secreted virions.
Discussion: Moreover, together with the results of chimeric constructs they suggest that mutations present at the N-terminus of 2A core protein (A36T or G63V) reduce the stringency of virion secretion, whereas mutations present at the C-terminus of the 4B core


  Expression of hepatitis B virus nuclear core antigen in young cirrhotic patients is associated with an unfavourable long-term outcome.
 PMID: 18647234       2008       Journal of viral hepatitis
Abstract: Sequence analysis revealed mutations on the nuclear localization signal (NLS) of core protein in five cirrhotic patients with nuclear HBcAg (Q171K in four and Q179K in one patients).
Abstract: Site-directed mutagenesis experiments demonstrated that both the Q171K and Q179K mutation enhanced nuclear localization of the core protein.



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