Result: M133I/L/T and Q129H/N/R had the highest prevalence in genotype B and M133I/L/T had the highest prevalence in Asia, also being present in >3% of the sequences (Figure 2B and 2C).
Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M (Figure 2A).
Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.
Introduction: Furthermore, the IEMs Q129N, M133T, and F134Y have been predicted to cause HBV diagnostic failure.
Discussion: There is no information about the transmissibility of sQ129H/L/R/N until today.
"Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in ""a"" Determinant."
PMID: 32922195
2020
International journal of medical sciences
8Discussion: According to the reports, the ""a"" determinant of OBI patients contains Gly145Arg/Ala/Ile/Trp/Glu (G145R/A/I/W/E), Leu109Arg (L109R), Gly119Arg (G119R), Pro120Thr (P120T), Lys122Ile (K122I), Thr126Asn (T126N), Thr127Arg (T127R), Gln129Asn (Q129N), Thr131Asn (T131N
Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
Method: Among them, sP120S/T/A, sT126N/S, sQ129R/N, sT131I/N, sM133I/L, sP142S, sD144A/E, sG145A/R were known to act as vaccine-escape mutations.
Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, Q129N and T131N/M133T in hepatitis B surface antigen (HBsAg) interfere with the immunogenicity of the corresponding HBsAg or viral replication ability.
1Abstract: Additional N-glycosylation-associated mutations, sQ129N and s131-133TSM NST, but not s126-127 ""RPCMNCTI,"" greatly attenuated anti-HBs binding to HBsAg."
1Abstract: RESULTS: Twenty-one preS/S-gene mutants were cloned from four sequential serum samples, including 13 mutants that were not previously documented: (1) sI/T126V+sG145R; (2) preS1 nt 3014-3198 deletion; (3) preS1 nt 3046-3177 deletion; (4) preS1 nt 3046-317
Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.
1Abstract: These changes involved 11 positions inside and 5 outside of the historical first and second loops of the ""a"" determinant, and included the following: Q101K, T115A, K122N, T123A, T126N, Q129N, G130R, T131I, M133T, F134L, C138Y, K141E, P142S, G145R, N146S, and C147F/R."
Detection of hepatitis B virus surface antigen mutants in paraffin-embedded hepatocellular carcinoma tissues.
1Abstract: Mutations on the ""a"" determinant (Thr126Ser, Gly145Arg, a double mutant Thr126Ser/Gln129Asn, Met 133Leu and Thr140Ile) were identified in 5 samples while the wild type sequence was found in 2 others."
Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene.
Abstract: Rare substitution was identified both at positions 129 (glutamine to asparagine) and at position 145 (glycine to alanine) in the 'a' determinant region, which is considered to be within a larger antigenic area known as the major hydrophilic region (MHR).
HBV mutation literature information.
PMID: 
2022
PloS one
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