8Discussion: Interestingly, the most frequently observed naturally occurring
core protein mutation found in
CHB and also in
HCC patients
I97L or
F97L which is associated with ""immature virion secretion"" was completely absent in Indian patients with HBV-genotype D while among the ""low secretion
core variants"" such as
P5T/A/S, a new variant
P5R was noted with high frequency in HBV-genotype D related
HCC in previous Indian study."