literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Introduction: In a study conducted in the Korean population, the five HBcAg mutations P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop were significantly more frequent in subjects with chronic hepatitis and cirrhosis.

The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.

PMID: 30406036 2018 Frontiers in cellular and infection microbiology

Introduction: Furthermore, five HBcAg mutations identified in a Korean population, P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop, were shown to be significantly enriched in HCC patients compared with patients at earlier disease stages, including those with cirrhosis and chronic hepatitis (Kim et al.,).

Introduction: Similarly, a study of an Indian population showed that HBcAg residue 5 mutations P5H/L/T or P5R were found more frequently in HCC pati

Upregulation of endoplasmic reticulum stress and reactive oxygen species by naturally occurring mutations in hepatitis B virus core antigen.

PMID: 25828947 2015 The Journal of general virology

Abstract: Here, we found that the naturally occurring mutations P5T/H/L of the HBV core antigen induced ER stress.

Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.

PMID: 24587360 2014 PloS one

Discussion: A recent study showed that HBV/C related P5H, I97F/L and L100I mutations were significantly associated with HCC.

Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV.

PMID: 23925707 2013 Journal of medical virology

Abstract: Other mutations (e.g., P5H/L and I97L) associated with severe liver disease were also noticed, some of which were located in the major histocompatibility restricted sites.

Discussion: P5H/L and I97L amino acid mutations in genotype C of HBV (all of which were noticed in this study) were recently found to be associated with HCC, and I97L was found at a higher frequency (16%) among study participants.

Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.

PMID: 23071796 2012 PloS one

Abstract: Six (preC-W28*, C-P5H/L/T, C-E83D, C-I97F/L, C-L100I and C-Q182K/*) and seven types (preC-W28*, preC-G29D, C-D32N/H, C-E43K, C-P50A/H/Y, C-

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