Result: The result found eight variables that composed of males (OR = 4.51, 95%CI 1.78-11.4, p = 0.001), age >=40 (OR = 5.5, 95%CI 2.06-14.68, p = 0.001), HBeAg negative (OR = 2.46, 95%CI 1.1-5.53, p = 0.029) and 5 point-mutations such as W4P/R/Y (OR = 11.56, 95%CI 1.99-67.05, p = 0.006), T47A/E/V/K (OR = 3.67, 95%CI 1.19-11.29, p = 0.023), P120S/T (OR = 3.38, 95%CI 1.09-10.49, p = 0.035), S174N (OR = 29.73, 95%CI 2.12-417.07, p = 0.012) and P203S (OR = 8.45, 95%CI 1.43-50.06, p = 0.019) had significant relations with HCC (Table 6).

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Discussion: Outside of the MHR region we also detected higher rates of other 3 S mutations T47

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