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 HBV mutation literature information.


  Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
 PMID: 35390033       2022       PloS one
Discussion: (2017) had stated that P203Q and the combination of P203R and S210R hampered the HBsAg secretion and increased cellular proliferation.
Discussion: The correlation of the C-terminus P203Q (17.4% vs 1.0%, p = 0.004), S210R (34.8% vs 3.8%, p<0.001) and of their combination with HCC had been reported in genotype A and D CHB patients.


  Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa.
 PMID: 30257068       2019       Liver international
Abstract: Twelve S-gene MUPIQHs were identified among 21 patients (28.8%): sS140L (n = 4), sD144A (n = 1), sS167L (n = 2), sS174N (n = 6), sP178Q (n = 2), sG185L (n = 2), sW191L (n = 2), sP203Q/R (n = 2), sS204N/I/R/K/T/G (n = 7), sN207T


  Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro.
 PMID: 28152517       2017       Oncotarget
Abstract: Furthermore, P203Q and P203Q+S210R increased the percentage of cells in S-phase compared to wt, indicating cell-cycle progression (P203Q:26+-13%; P203Q+S210R:29+-14%; wt:18%+-9, P <0.01.
Abstract: In in-vitro experiments, P203Q, S210R and P203Q+S210R significantly reduced the ratio [secreted/intracellular HBsAg] compared to wt at each time-point analysed (P <0.05), supporting an impaired HBsAg-secretion.
Abstract: RESULTS: Two HBsAg mutations significantly correlated with  PMID: 25503289       2014       PloS one
Table: P203Q



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