HBV mutation literature information.


  Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.
 PMID: 31516090       2019       Emerging microbes & infections
Discussion: However, in a previous study the OBI-associated P178R substitution prevented HBsAg secretion in two distinct OBI clones and in M88.


  Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection.
 PMID: 23658444       2013       Journal of virology
Abstract: However, the P178R substitution present in all cloned sequences of two OBI strains may contribute significantly to the OBI phenotype.
Abstract: The substitution M75T, Y100S, or P178R was present in 4/6 pattern 2 OBI clones.



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