ViMRT
}  
 
Home   
< Docs   

 HBV mutation literature information.


  Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model.
 PMID: 31462567       2019       Journal of virology
Abs
Abstract: Although mutant P130T also displayed a hypermaturation phenotype in vivo, it cannot efficiently rescue the immature virion secretion of mutant I97L.
Abstract: Although viral DNA of mutant I97L with immature genome is less persistent than wild-type HBV in time course experiments, viral DNA of mutant P130T with genome hypermaturation, surprisingly, is more persistent.


  Early changes in quasispecies variant after antiviral therapy for chronic hepatitis B.
 PMID: 29393485       2018       Molecular medicine reports
Abstract: Furthermore, several mutation patterns, such as cI97L and cP130T showed alterations in the secondary structure and predicted antigenicity of HBV protein.


  Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
 PMID: 23951004       2013       PloS one
Result: P130T in the C region and A90V/S in the pre-S1 regions were observed in 2 and 6 isolates, respectively.


  Hepatitis B virus core protein variations differ in tumor and adjacent nontumor tissues from patients with hepatocellular carcinoma.
 PMID: 21325784       2012       Intervirology
Abstract: The most frequently occurring mutations in rank were codon P130T (38.8%), I97L (37.8%) and S87G (23.5%).


  Naturally occurring core immune-escape and carboxy-terminal mutations runcations in patients with e antigen negative chronic hepatitis B.
 PMID: 26201521       2012       Hepatology international
Abstract: CONCLUSION: Core immune-escape mutations cT12S, cS21T, cT67P, cE113D, and cP130T/Q are significantly higher in decompensated liver disease patients and could influence the severity of liver disease in HBeAg -ve CHB patients.
Abstract: When frequency of core immune escape mutations was compared among CHB and decompensated patients, and c PMID: 20184927       2010       Virus research
Abstract: In the core protein, cI3L, cL60M, and cI97L were detected in 8 of 10 clones and cP130T was detected in all 10 clones.


  Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
 PMID: 19327810       2009       Virology
Discussion: An F97L mutation causes the immature secretion phenotype, which could be overcome by a P130T mutation.


  Properties of hepatitis B virus genome recovered from Vietnamese patients with fulminant hepatitis in comparison with those of acute hepatitis.
 PMID: 10745228       2000       Journal of medical virology
Abstract: The missense mutations within the core region, Ile97Leu and Pro130Ile/Thr/Ser, were also remarkable in fulminant hepatitis.
Abstract: The results with the Vietnamese cases of fulminant hepatitis corroborated results of previous studies with respect to the mutations Trp28Stop of precore and Ile97Leu and Pro130Ile/Thr/Ser of core, but not for the mutations within Enh II and precore/core promoter region.


  A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L).
 PMID: 10775637       2000       Journal of virology
Abstract: Our current study demonstrates that this abnormality can be efficiently offset by another frequent core mutation, P130T.



Browser Board

 Co-occurred Entities




   Filtrator