The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Table: P130Q
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Abstract: BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p < 0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.
Abstract: Multivariate risk analysis had confirmed that core_P130Q
Naturally occurring core immune-escape and carboxy-terminal mutations runcations in patients with e antigen negative chronic hepatitis B.
Abstract: CONCLUSION: Core immune-escape mutations cT12S, cS21T, cT67P, cE113D, and cP130T/Q are significantly higher in decompensated liver disease patients and could influence the severity of liver disease in HBeAg -ve CHB patients.
Abstract: When frequency of core immune escape mutations was compared among CHB and decompensated patients, and c
HBV mutation literature information.
PMID: 
2018
Frontiers in cellular and infection microbiology
