Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia.
HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg.
1Abstract: We generated a series of expression constructs of variant HBsAg with ""a"" determinant amino acid substitutions including P127L, P127T, S136Y, and P127T + S136Y using site-directed mutagenesis."
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: However, out of these 20 S-substitutions, 10 (sT114S, sT126I, sP127T, sN131T, sN143S, sY/S161F, sA194V, sI195M, sW196L and sR210N) remained significant after application of Benjamini-Hochberg correction (Table 2).
Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.
Abstract: Among them, three mutations, S114T, P127S/T, M133T, were detected in common.
Discussion: P127T, found in four of six patients with mutations, appears to be a meaningful mutation contributing to the occurrence of occult HBV infection.
Discussion: The 'a' determinant mutations found in this study were I126M/N, P127S/T, T131N, S132F, M133T, F134L/T, D144E, and G145A.
HBV mutation literature information.
PMID: 
2022
PloS one
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