Introduction: (n = 187) had reported a rate of 31% cases with point-mutation in the immunodominant 'a' region, especially two major vaccine escape mutations with minor rates as G145A/R (2.2%) and P120L/Q/S/T (5.3%) had been detected.
Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.
Discussion: All sequences obtained in this study were classified as HBV genotype E, which is known to show a clear genotypic divergence from all genotypes within the a determinant, where escape mutations can occur, reported that the types of polymorphisms at positions associated with escape mutations observed in HBV vary from one genotype to another and that the most common of these polymorphisms found in genotype E are T116N, P120L/S, Q129H/R, M133I, D144E, and G145I.
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.
Result: In particular, mutations were detected in 67/63
Molecular characterization of hepatitis B virus in blood donors in Botswana.
Abstract: The escape mutations sP120L, sG130R, sY134H, and sD144A were identified predominantly among HBV isolates from blood donors.
Result: Three of 5 (60%) escape mutations isolated from sequences from blood donors resided within the 'a' determinant's first loop (aa 124-137), 1 (20%) within the second loop (aa 138-147), and P120L was present in the mini loop outside the range (aa 124 -147).
Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K,
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively.
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1),
HBV mutation literature information.
PMID: 
2022
PloS one
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