literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Introduction: (2017) described more concretely about point-mutations (N38E 71.9%, N38K 71.1%, A60V/E 100% on the PreS1 region, L126T/S 77% on the PreS2 and N3S 27.4% on the S region).

Discussion: (2017) (N38E 71.9%, N38K 71.1%, A60V/E 100% on the PreS1 region, L126T/S 77% on the PreS2 and N3S 27.4% on the S region), from Kim et al.

PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh.

PMID: 31952213 2020 International journal of molecular sciences

Abstract: Clinically significant mutations, such as preS1 C2964A, reverse transcriptase domain I91L, and small HBsAg N3S, were identified.

Result: Small HBsAg showed the following mutations: N3S, V18G, E44G, M47T, S53L, V159A, A177V, S210N, and I213L; none of these are associated with HBsAg escape, though the N3S mutant is associated with an increased risk of

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S, V184A, and S204R)."

Result: N3S mutation was significantly higher in genotype C isolates (p < 0.001) isolates (Table 2).

Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.

PMID: 28939157 2017 Vaccine

Abstract: More importantly, N3S, L21S, T47K, L98V, I/S126T and L213I mutations were detected in 1 (2.5%), 1 (2.5%), 1 (2.5%), 3 (7.5%), 1 (2.5%), 1 (2.5%) genotype C HBV infected Chinese younger with neonatal HBV vaccination, respectively.

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