Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.
Result: Out of 24 mutations of L229 (Table 3), 18 were associated to M204I or V; 2 coexisted with F221Y (Table 4); 2 were associated to A181T; 2 were associated to V207M (Table 4) and N236V, respectively.
Table: N236T/V
Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients.
Abstract: rtN236V mutants emerged predominantly with virological breakthrough in the clinical course of the six patients.|m
Abstract: BACKGROUND: The study aimed to clarify whether rtN236V mutation of HBV derived from adefovir dipivoxil (ADV)-refractory patients was associated with drug resistance.
Abstract: CONCLUSIONS: rtN236V was a novel infrequently occurring ADV-resistance-associated mutation.
Abstract: RESULTS: rtN236V was detected in six ADV-refractory patients; signature ADV-resistant mutations rtA181V and rtN236T were detected in 1,311 patients.
[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly].
Abstract: In one patient after stopping the adefovir therapy, 3 months later a wild type virus re-took again the mutant one (rtN236T); in one patient who developed a rt236T mutant after 132 weeks of adefovir treatment, a novel mutant (rtN236V) appeared and then became the dominant one while adefovir treatment continued.
HBV mutation literature information.
PMID: 
2022
Frontiers in microbiology
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