literature

HBV mutation literature information.

Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.

PMID: 35102169 2022 Scientific reports

Table: N123D

Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.

PMID: 30867996 2019 PeerJ

Table: N123D

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

PMID: 29434654 2018 Infectious agents and cancer

Abstract: The minor populations of variants harbouring the W4R, L30S, Q118R/Stop, N123D and S124F/P mutations in the pre-S region and the L21F/S and L42F/S mutations in the S region were detected more frequently in OBI-related HCC than in HBsAg-positive HCC.

Result: The different mutations detected were W4R, S5A/P/T, L30S, G35R<

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Result: Amino acid substitutions in mother include T16I, R41S, V44A,N53S, H55R, W58R, N76D, S81T, V103I, G107E, N121I, I122L, N123D, Q125K, H126Y, N134D, N139H, N139Q, Y158H, I163V, F178L, S185N, V207M

Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.

PMID: 25061278 2014 Drug design, development and therapy

Discussion: In vitro drug susceptibility showed that TDF displayed one- to twofold resistance to ETV-resistant viral strains (N123D + H124Y + L180M + S202G + M204V + Y257H, I163V + L164M + L180M + S202G + M204V + C256S, and H124Y + L180M + S202G + M204V + Y257H).

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