Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Result: Five AA sites identified with the significantly elevated entropy levels were rtL180M, rtA181T/V/I, rtM204I/V/L, rtL229V/M/F, rtN236T/I, four of which had been widely known already as classical resistance mutation.
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Discussion: In this study, using next-generation sequencing, mutations were found at rt202 (rtS202R/I/N/C/G), rt204 (rtM204L/R/I), rt236 (rtN236T/K/H), and rt250 (rtM250I/L) (Table 5).
HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining.
Abstract: Secondary substitutions (rtL80V and rtV173G/A/L) occurred more frequently than primary NUCr substitutions (rtI169L; rtA181G; T184A/S; rtS202T/R; rtM204L and rtM250K).
Result: However, the relationship between other atypical AA substitutions with susceptibility to NUCs has not been characterized in vitro, such as rtI169L (not typical r
Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.
PMID: 26220282
2015
BMC complementary and alternative medicine
Method: The YMDD (203tyrosine-methionine-aspartate-aspartate206) RT active site mutants M204A, M204I, M204K, M204L, M204R, M204T, and M204V, were then constructed by PCR-derived mutagenesis.
A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians.
Abstract: The proportions of the total number of reads containing mutations I169L/M, S202R, M204I/L or N236S were >1.0%.
Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues.
Abstract: Univariate statistical analyses showed that possible prognostic indicators for the occurrence of BTH were pre-S deletions ( P = 0.03) and L180M/M204L mutations ( P = 0.04).
HBV mutation literature information.
PMID: 
2020
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