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 HBV mutation literature information.


  Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.
 PMID: 30835025       2019       Digestive diseases and sciences
Abstract: Multivariate analysis showed that the independent factors for SAE were V14G/A and L21S in surface genes, codons 109-119 deletions in pre-S1 genes, M1V/T/I in pre-S2 genes, and C1766T/T1768A and C1913A/G mutations in BCP/PC genes.


  Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
 PMID: 30584239       2018       Scientific reports
Abstract: Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region.
Result: Indeed, ultra-deep sequencing analysis showed that almost all the reactivated viral clones in four cases in the non-HSCT group were variants with the M1I/V substitution at the PreS2 start codon (frequency of 99.7% to 99.9% for total viral population), suggesti



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