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 HBV mutation literature information.


  Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.
 PMID: 30835025       2019       Digestive diseases and sciences
Abstract: Multivariate analysis showed that the independent factors for SAE were V14G/A and L21S in surface genes, codons 109-119 deletions in pre-S1 genes, M1V/T/I in pre-S2 genes, and C1766T/T1768A and C1913A/G mutations in BCP/PC genes.


  Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
 PMID: 30584239       2018       Scientific reports
Abstract: Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region.
Result: Indeed, ultra-deep sequencing analysis showed that almost all the reactivated viral clones in four cases in the non-HSCT group were variants with the M1I/V substitution at the PreS2 start codon (frequency of 99.7% to 99.9% for total viral population), suggesti


  Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.
 PMID: 24409056       2013       World journal of gastroenterology
Abstract: The preS2 start codon M1T/I mutation was unique to genotype A strains (15.6%) from all disease groups and occurred at a higher frequency in isolates from HCC patients (P = 0.076).


  Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa.
 PMID: 23029487       2012       PloS one
Discussion: These included ps1F25L, ps1I48V, ps1V88L/A in the pre-S1 region, ps2M1I, ps2Q10R, ps2R48K/T, ps2A53V in the pre-S2 and sY100C, sP120T/A, sQ129R/H, s<


  A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.
 PMID: 19431214       2009       International journal of cancer
Abstract: Compared with the HBsAg-positive HCC controls, occult HBV-infected HCC patients had higher frequencies of M1I and Q2K in pre-S2 gene, G185R and S210N in surface gene, A36T and A44L in X gene, and G1721A in enhancer II gene, and had lower rates of pre-S deletions and A1762T/G1764A,



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