8Discussion: Demonstration of a common M125T mutation amongst all samples sequenced resonates with the fact that point mutations are frequently observed in the first loop of the ""a"" epitope (a.a.124-147) of the surface antigen in OBI isolates."

---

Abstract: In addition, a virus surface antigen mis-sense mutation resulting in M125T was detected in all the samples and could account for surface antigen negativity and occult HBV status.

---

Result: All the mutations were synonymous, except T528C which resulted in an amino acid change (Met125Thr) in the 'a' determinant of the S protein.

---