literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: The point-mutations with the rates of over 30% were T125S/N/P (30.8%), I150T (42.5%), and V158A (36%); from 10 to <30% of population were M120V/I (11.3%) and F141V/L/I (11.3%); and from 5 to <10% of population were Q121R/K (5.3%), T164I/D/S (6.1%), and F165S/L (5.7%).

Table: M120V/I

Pre-S2 Start Codon Mutation of Hepatitis B Virus Subgenotype B3 Effects on NF-kappaB Expression and Activation in Huh7 Cell Lines.

PMID: 29652648 2018 Viral immunology

Abstract: A cross-sectional study on hepatitis B patients in Indonesia showed association of pre-S2 start codon mutation (M120 V) with cirrhosis and hepatocellular carcinoma (HCC), which was dissimilar from studies from other populations where pre-S2 deletion mutation was more prevalent.

Abstract: HBV subgenotypes B3, each carrying wild-type (wt) HBs, M120 V, and pre-S2 deletion mutation were isolated from three HCC patients.

Abstract: However, M120 V mutation may utilize a different pathway in

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