literature

HBV mutation literature information.

Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.

PMID: 35102169 2022 Scientific reports

Table: M103I

Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.

PMID: 33468062 2021 BMC infectious diseases

Table: M103I

Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.

PMID: 31269905 2019 BMC infectious diseases

Table: M103I

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: M103I

Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.

PMID: 27182775 2016 PloS one

Table: M103I

Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.

PMID: 25418031 2015 Hepatology (Baltimore, Md.)

Abstract: Of the 13 HBsAg mutations found in these patients, 8 of 13 (M103I-L109I-T118K-P120A-Y134H-S143L-D144E-S171F) reside in a major hydrophilic loop (target of neutralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral response.

Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.

PMID: 24009186 2014 Journal of medical virology

Abstract: Unique sequence variants at amino acid positions M103I, L109P, S117R, F134I, and S136L found in this study have not yet been reported.

Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.

PMID: 24587360 2014 PloS one

Result: In addition, other mutations such as Y100D, Q101R/H, M103V/I, D144E and G145S was also found within the major hydrophilic loop (MHL) of the S gene.

Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.

Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.

PMID: 22967103 2012 Journal of viral hepatitis

Abstract: Site-directed mutagenesis was then utilized to introduce three genotype A mutations - M103I, K122R and G145A - associated with occult HBV infection in vivo, alone and in combination, into the wild-type HBsAg vectors.

Introduction: M103I had been previously identified in 2 O-HBV infections, although these patients harbored genotype C or D.

Introduction: Three O-HBV mutations - M103I, K122R, and G145A - from a genotype A infection were significant by signature pattern analysis.

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