A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1.
Figure: A nonsense mutation at the codons for L95, W182 and L216 resulted in sL95*, sW182* and sL216*, respectively.
Discussion: The three nonsense mutants, designated sL95*, sW182* and sL216*, have been shown to have oncogenic property and sW182* was the most potent.
Identification of transforming hepatitis B virus S gene nonsense mutations derived from freely replicative viruses in hepatocellular carcinoma.
Abstract: Three nonsense mutations of S gene (sL95*, sW182*, and sL216*) were identified in the HBcAg(+) HCC tumor tissues.
Method: To construct plasmids encoding truncated preS/S proteins containing 3 nonsense mutations, sL95*, sW182* and sL216*, respectively, site directed mutagenesis experiments were preformed according to a PCR-based method.
HBV mutation literature information.
PMID: 
2019
PloS one
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