Abstract: Only mutations
C85R,
L87R,
L88R, and
C90R within TMD2 were associated with defective
HBsAg production.
Result: Seven
OBI-specific substitutions introducing an arginine residue in
S TMDs were investigated:
Q16R in TMD1,
C85R,
L87R,
L88R, and
C90R in TMD2, and
Q181R and
W182R in TMD3.
Result: When introduced in M88 and P38.II, mutations
C85R,
L87R,
L88R, and