literature

HBV mutation literature information.

Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naive chronically infected patients.

PMID: 31179360 2019 Virusdisease

Abstract: Two substitutions N459Y and L515M were significantly correlated (R2 = 0.486 and R2 = 0.941 respectively) with FLLAQ motif variation.

[Clinical study of oligonucleotide microarray on monitoring the lamivudine-resistance mutations in hepatitis B virus].

PMID: 12837218 2003 Zhonghua gan zang bing za zhi

Abstract: The most common mutated type was M539V+L515M and next M539I.

Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.

PMID: 10091998 1999 The Journal of general virology

Abstract: The M539I substitution in the conserved YMDD motif occurs independently of other changes, whereas the M539V substitution is associated with an additional upstream change (L515M).

Abstract: The L515M and M539V mutations provided only partial resistance while the M539I mutation conferred a high degree of lamivudine resistance.

Abstract: The combination of the L515M and M539V mutations gave an intermediate level of replication competence, compared with either mutation alone, and increased resistance to lamivudine.

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective.

PMID: 9462667 1998 Hepatology (Baltimore, Md.)

1Abstract: In addition, other mutations in the reverse-transcriptase ""B domain"" involving either a phenylalanine (F)-to-leucine (L) at amino acid 501 (F501L) or an L-to-M substitution at amino acid 515 (L515M) have been observed during 3TC and Famciclovir therapy as well."

Abstract: Double mutants with the L515M substitution showed intermediate defect between the YI/VDD or F501L and the L515M single-mutant strains.

Abstract: In contrast, when transfected into HEK 293 cells, the viruses bearing the YI/VDD or L515M mutation replicated as wild-type.

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