literature

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: Exceptionally, 13 S mutations presented the higher distributions (p<0.1) in the HCC group: F20S (8.2% vs 1%, p = 0.015), D33G (4.1% vs 0%, p = 0.039), (T47A/E/V/K (18.4% vs 7.1%, p = 0.025), R79H (6.1% vs 0%, p = 0.007), L88P (4.1% vs 0%, p = 0.039), P120S/T (on the MHR region, 16.3% vs 6.6%, p = 0.042), G145R (6.1% vs 1%, p = 0.055), S174N (6.1% vs 0.5%, p = 0.026), V190A (6.1% vs 0.5%, p = 0.026), P203R (8.2% vs 2%, p = 0.052), Y206H/F/C (6.1% vs 1.5%, p = 0.094),

PMID: 32997000 2020 Memorias do Instituto Oswaldo Cruz

Table: L209V

Mutation profiling of the hepatitis B virus strains circulating in North Indian population.

PMID: 24637457 2014 PloS one

Table: L209V

Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.

PMID: 25503289 2014 PloS one

Result: L209V was the only amino acid exchange detected in the S gene of the three A2 Palestinian genotypes, due to T779G point mutation.

Discussion: In the second report, authors propose that antibodies produced due to vaccination may not be effective in neutralizing HBV mutants including the L209V in genotype E.

Discussion: None of the six non-synonymous mutations found in the only Palestinian D3 sample was attributed to critical functional impact on viral activity (Table 3), in contrast, L209V, the only mutation found in the S gene of all three Palestinian A2 samples was reported in transplant recipients, who received HBIG and in vaccinated individuals.

Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.

PMID: 16954295 2006 Journal of clinical microbiology

Abstract: Both sisters carried an unusual L209V substitution within HBsAg.