Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.
PMID: 15980328
2005
Antimicrobial agents and chemotherapy
Abstract: The mutant had a rtL180C/M204I genotype and was detected after 2 years of therapy with lamivudine.
Abstract: Transient transfection studies in human hepatoma cells with HBV carrying the new mutant demonstrated that the rtL180C/M204I mutant was resistant to lamivudine up to 10 microM.
HBV mutation literature information.
PMID: 
2005
Antimicrobial agents and chemotherapy
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