Result: Among them, 4 point-mutations W4P/R/Y, S5L/T, A90T/S/G, and L108V/I were observed with the significantly higher rates in the HCC group compared to non-HCC group: W4P/R/Y (12.2% vs 2%, p = 0.005), S5L/T (6.1% vs 1%, p = 0.055), A90T/S/G (6.1% vs 0.5%, p = 0.026) and L108V/I (6.1% vs 0.5%, p = 0.026) (Table 2).

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Table: L108V/I

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Discussion: They were W4P/R/Y and S5L/T (p = 0.055) on the NTCP region;