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 HBV mutation literature information.


  "Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in ""a"" Determinant."
 PMID: 32922195       2020       International journal of medical sciences
8Discussion: According to the reports, the ""a"" determinant of OBI patients contains Gly145Arg/Ala/Ile/Trp/Glu (G145R/A/I/W/E), Leu109Arg (L109R), Gly119Arg (G119R), Pro120Thr (P120T), Lys122Ile (K122I), Thr126Asn (T126N), Thr127Arg (T127R), Gln129Asn (Q129N), Thr131Asn (T131N


  HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
 PMID: 27167598       2017       Antiviral therapy
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (


  Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
 PMID: 27650283       2017       Journal of hepatology
Introduction: It is known that new qHBsAg assays have incorporated the impact of some classical SHBs AA substitutions on qHBsAg, such as sK122I, sI126S and sG145R.


  Amino acid substitutions at positions 122 and 145 of hepatitis B virus surface antigen (HBsAg) determine the antigenicity and immunogenicity of HBsAg and influence in vivo HBsAg clearance.
 PMID: 22301154       2012       Journal of virology
Abstract: A variety of amino acid substitutions, such as K122I and G145R, have been identified around or within the a determinant of hepatitis B surface antigen (HBsAg), impair HBsAg secretion and antibody binding, and may be responsible for immune escape in patients.
Abstract: Genetic immunization in mice demonstrated that the priming of anti-HBs antibody response was strongly impaired by the substitutions K122I, G145R, and others, like G145I, G145W, and G145E.
Abstract: Only the substitution K122I at position 122 affected


  Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication.
 PMID: 19812261       2010       The Journal of general virology
Abstract: DNA immunization in BALB/c mice revealed that wtHBsAg and vtHBsAg with T123N and K160N are able to induce antibodies to HBsAg (anti-HBs), whereas
Abstract: Detection of HBsAg by ELISA and immunofluorescence staining indicated that variant HBsAg (vtHBsAg) with K122I was not recognized by HBsAg immunoassays, while vtHBsAg with T123N, A159G, K160N and A159G/K160N had reduced antigenicity.


  [Antigenicity of major hydrophilic region II of hepatitis B virus surface antigen].
 PMID: 17362631       2007       Zhonghua gan zang bing za zhi
Abstract: METHODS: Four recombinant plasmids expressing mutant HBsAg (mtHBsAg) P1120T, C121S, K122I and T123N were constructed.
Abstract: The immunoreactivity of the cells expressing mtHBsAg with P1120T, C121S, K122I, T123N and G145R were detected by immunofluorescence (IF) staining and ELISA with 4 antibodies and 7 HBsAg diagnostic kits respectively.
Abstract: mtHBsAg with C121S and K122I was not recognized by any mAbs.



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