Result: The mutations with a rate over 30% were N51Y/T/S/Q/P 30.4%, V68T/S/I 44.9%, and T/N87S/T/P 46.2%; from 10 to <30% were Q10K/H/R (16.2%), H48Y/N (13.8%), E/D54A/N (25.1%), I/N56H/W (25.9%), K57Q/K (25.1%), A60V (25.5%), D/A62S/T (25.1%), G73S/N (24.3%), and V95A (24.3%); and from 5 to <10% were G35R/K (8.5%), and I84V/M/L (7.7%).
Table: I
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Result: Of the four rt269I signature types, I84T/M/L/V in PreS1 has been reported to be frequently found in HBV occult cases.
Result: We found a total of five types of signature NS mutations in the S ORF (I84T/M/L/V and A90T/V in PreS1, F141L in PreS2, and I68T and L213I/S in S).
Table: I84T/M/L/V
Discussion: Indeed, we found several rt269I signature mutation types related to lower HBV replication (
HBV mutation literature information.
PMID: 
2022
PloS one
