rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Result: Of these, the frequency in all four types but one rt269L signature type (I68T in the S region) was significantly or tended to be higher in rt269I HBV strains than in rt269L.
Result: The rt269L signature type, I68T in the S region, which is significantly prevalent in the rt269L versus rt269I type (q = 0.004), has been reported to be an HCC-independent risk factor in chronic Chinese patients with genotype C infections.
Result: We found a total of five types of signature NS mutations in the S ORF (I
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission.
2Conclusion: Although P56L, I68V, and I68T were detected as a minor population in the three umbilical cord samples, there was no variant in the ""a"" determinant region of HBsAg gene from the three umbilical cord samples."
Conclusion: I68T was detected in both the serum and nails of the 1st-born and 2nd-born children.
Table: I68T
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: After implementing Benjamini-Hochberg correction, 3 (rtM204I, rtL80I, rtY54H) out these 7 RT substitutions and 6 (sS45A, sP46T, sI68T/A, sT118V, sW196L and sR210N) out of 8 S-substitutions remained significantly less frequent in the responders (Table 4).
Result: However, at the end of 24-
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Result: By linkage analysis, the stop codon in the S-open reading frame (S-ORF) was always linked to sI68T, which is a silent mutation in polymerase-ORF (Table 1).
Result: While sC69* is invariably linked to sI68T, rtS78T seems to occur preferentially alone, and only in very low percentages with other variants.
Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
Result: In one case, A159G and R160K amino acid changes were found, and in the other, I68T amino acid substitution was observed.
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Result: Other mutations that we detected in the S gene include S3N (Group P=4, Group C=2), I68T (Group P=3, Group C=1), I126T (Group P=4, Group C=1), and L213I (Group P=6, Group C=1).
Combined mutations in pre-s/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study.
PMID: 18939932
2008
The Journal of infectious diseases
Abstract: CONCLUSIONS: Pre-S deletions, I68T in surface gene, T1762/A1764, and A1899 were independent risk factors for HCC.
Abstract: Multivariate analysis showed that pre-S deletions, I68T surface gene, T1762/A1764, and A1899 were independent factors associated with the development of HCC.
HBV mutation literature information.
PMID: 
2022
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