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 HBV mutation literature information.


  Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
 PMID: 29315352       2018       PloS one
Result: The MRT revealed I169L mutation in one patient (Fig 4, Table 4).
Table: I169L
Discussion: A single HBV strain has an I169L mutation, at a position associated with resistance to Entecavir, although leucine (L) is not the amino acid involved.


  Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
 PMID: 29408943       2018       PloS one
Table: I169L


  Genetic variability in coding regions of the surface antigen and reverse transcriptase domain of hepatitis B virus polymerase, Colombia, 2002-2014
 PMID: 30184362       2018       Biomedica
Abstract: The L180M and M204V resistance mutations were simultaneously identified in one sample, while the I169L resistance mutation was identified in another one.


  Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
 PMID: 30202825       2018       Hepatology communications
Table: I169L


  Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
 PMID: 28325923       2017       Emerging microbes & infections
Result: We also screened several mutations relevant to antiviral resistance, such as I169L, L180M, A181V, T184I, S202C, M204V/I, N236T and M250I in the RT region.


  HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining.
 PMID: 28749433       2017       Viruses
Abstract: Secondary substitutions (rtL80V and rtV173G/A/L) occurred more frequently than primary NUCr substitutions (rtI169L; rtA181G; T184A/S; rtS202T/R; rtM204L and rtM250K).
Result: However, the relationship between other atypical AA substitutions with susceptibility to NUCs has not been characterized in vitro, such as rtI169L (not typical r


  Antiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent.
 PMID: 24399391       2014       Indian journal of medical microbiology
Abstract: On sequence analysis, two subjects were identified with rtI169L and rtA181V mutation after 9 months and 18 months of adefovir treatment, respectively.


  A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians.
 PMID: 25382636       2014       Intervirology
Abstract: The proportions of the total number of reads containing mutations I169L/M, S202R, M204I/L or N236S were >1.0%.


  Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
 PMID: 23710315       2013       Gut and liver
Abstract: In patient 3, mutations conferring resistance to adefovir at V84I (5%), I169L (1%), and N236H (7%) and entecavir at S202G (2%) were detected.
Abstract: Patient 4 had mutations at T128N (1%), I169L (1%), V173L (2%), A181V (1%), and Q215H (1%).
Result: In patient 1, 3, and 4, I169L substitution was also detected.


  Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
 PMID: 22666402       2012       PloS one
Table: I169L



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