Method: In addition, a combination mutant of
I127N/
K130M/V131/
I/F132Y (abbreviated as Combo mutant) was generated.
Discussion: Our results in HepG2 and Huh7cells indicate that Combo mutant
HBx I127N/
K130M/V131/
I/F132Y with changes corresponding to
core promoter mutations
T1753A/
A1762T/
G1764A/
T1768A that are typically found in patients close to the time of diagnosis of
HCC decreased p21 expression while TA double mutation or o
HBV mutation literature information.
PMID: 
2011
Gastroenterology
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