literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: The point-mutations on the S gene that owned the rates of >30% of the population were: S53L (37.7%), A184V/G (39.3%), and S210K/N/R/S (39.3%); from 15 to <30% were L21S (29.1%), G44E/V (18.6%), I126T/N/S (21.1%), and M198I/M (18.2%); and from 5 to <15% were V14A/G/Q (10.1%), N40S/K (6.9%), T47A/E/V/K (9.3%), P/L49R/H (5.7%), P62Q/L (9.7%), C76Y/T/W (10.5%), Y100C/F

The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing.

PMID: 34899733 2021 Frontiers in immunology

Abstract: Especially, mutations in antigenic epitopes, such as I126S in CHB and I126T in HCC, could impact the conformational structure and alter the antigenicity/immunogenicity of HBsAg.

"Characteristics of amino acid substitutions within the ""a"" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs."

PMID: 31624004 2020 Clinics and research in hepatology and gastroenterology

Abstract: The most frequent amino acid substitution was located at position s126 and the predominant substitution was sI126T in HBsAg+/anti-HBs+ patients with genotype C.

Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.

PMID: 31269905 2019 BMC infectious diseases

Result: In genotype C, vaccine escape related mutations T47K (13.0%), T116 N (4.3%), I126T (8.7%), Q129R (8.7%) and G145A/R (17.4%) were found.

The modulation of HBsAg level by sI126T is affected by additional amino acid substitutions in the S region of HBV.

PMID: 31442597 2019 Infection, genetics and evolution

Abstract: Among different substitution types at sI126, the sI126T (N = 28) was found to be associated with significantly lower serum HBsAg level.

Abstract: Clone sequencing revealed that sI126T-harboring SHBs sequences had varied genetic backbones with zero to nine additional AA substitutions.

Abstract: Our findings suggest that the modulation of HBsAg level by sI126T is affected by additional AA substitution(s) in the S region of HBV.

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

PMID: 29434654 2018 Infectious agents and cancer

Result: I126S/T, known as an escape mutation in the alpha determinant region, was found only in HBsAg-positive HCC (Table 3).

Result: Differences in the major populations were attributed to the I126S/T, Y200F/S, and Y206C/H/S mutations, while those in the minor populations were attributed to the L21F/S, L42F/S, W182Stop, and L213F/I/T mutations.

Table: I126S/T

Discussion: In present study, I126S/T mutants were detected only in

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.

PMID: 27650283 2017 Journal of hepatology

Result: revealed previously identified immune escape mutations within the 'a' determinant region (sS117T, sK122R, sI126N/S/T, and sG145R), carboxyl terminal truncation mutations (sC69* and sW182*) and additional rarely described mutations (sE2G, sL21S, sR24K, sT47K/A

Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.

PMID: 28325923 2017 Emerging microbes & infections

Discussion: In contrast, the frequencies of L110I, T113S and I126T, which may be compensatory mutations, increased in the S region.

Discussion: In the present study, data from ultra-deep sequencing revealed that mutants harboring different mutations, including G145R and I126T, coexisted in the patient.

Discussion: The presence of amino-acid substitutions in the MHR of HBsAg, such as G145R and I126T, can change the immunogenicity of HBsAg, thus resulting in HBsAg/anti-HBs coexistence and immune escape.

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Result: Only I126T was found in five subjects of the control group (C4, C8, C15, C16, and C20), although this mutation was not found in the occult HBV infection group.

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