Discussion: The differences between our ayw strain and the much tighter-binding CW-variant are four residues (V74N; S87N, F97I, I116L), which do not contact the peptide directly.
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Abstract: BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p < 0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.
Result: Few other mutations E113Q (36%), I116L (50%) and
HBV mutation literature information.
PMID: 
2021
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