Association between host TNF-alpha, TGF-beta1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Discussion: H94Y and I127L/T/N/S mutations have been associated to K130M/V131I in previous studies.
Discussion: The H94Y mutation causes changes in the alpha box, an element strongly activating the EnhII/core promoter, and increase the binding affinity of the alpha box and EnhII/core promoter.
Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.
Abstract: H94Y and K130M mutations were also significantly associated with severe liver disease.
Result: Furthermore, multivariate regression analysis revealed that HBV viral load (p < 0.0001), mutation from H to Y at aa94 with (p = 0.011), and mutation from F to Y at aa132 (p = 0.035) were independently associated with LC+HCC (Table 5).
Result: Univariate analysis showed that age (p < 0.0001), HBV viral load (p < 0.0001), mutation from A to S at aa47 (p = 0.047), mutation from H to Y at aa94 (p = 0.002), mutation from I to T at aa127 (p = 0.001), mutation from F
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Result: It is noteworthy, that the C69stop codon mutation in the surface gene, the C1766T /T1768A mutation in the basal core promoter and the H94Y mutation in the x gene were found only in chronic patients.
Result: Substitution H94Y was absent in acute infection.
Discussion: Among them the C69stop codon mutation in the surface gene, the C1766T /T1768A mutation in the basal core promoter and the H94Y mutation in the x gene were found only in chronic patients sh
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Discussion: 116-127) of HBx are frequently altered in HBV-genotype C and B, but no significant sequence heterogeneity was noted in the epitopes of HBV-genotype D, except three mutations I127T (T1753C), K130M (A1762T) and V131I (G1764A), though H94Y (T1653C) was present with high frequencies in both LC and HCC (Table 3) as observed in previous study.
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Discussion: In addition, the C1653T, T1753C, A1762T, and G1764A mutations lead to H94Y, I127T, K130M, and V131I amino acid substitutions in HBx.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Discussion: In addition, this mutation changes the aa 94 (H94Y) in the HBx protein, which affect the transactivation effects of this protein.
Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Abstract: All five mutation types (V5M/L, P38S, H94Y, I127T/N, and K130M and V131I) affecting the six codons were found to be related significantly to clinical severity.
Mutations in the transcriptional regulatory region of the precore and core/pregenome of a hepatitis B virus with defective HBeAg production.
Abstract: The deduced amino acid substitutions were 28 Arg--Gln, 94 His--Tyr, 131 Val--Ile and 132 Phe--Tyr of HBx and 715 Met--Val and 789 Asp--Asn of pol.
HBV mutation literature information.
PMID: 
2019
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