literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Abstract: The most common point-mutations included N/H51Y/T/S/Q/P (30.4%), V68T/S/I (44.9%), T/N87S/T/P (46.2%) on PreS1 gene; T125S/N/P (30.8%), I150T (42.5%) on PreS2 gene; S53L (37.7%), A184V/G (39.3%), S210K/N/R/S (39.3%) on S gene.

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

PMID: 29434654 2018 Infectious agents and cancer

Result: The different mutations detected were W4R, S5A/P/T, L30S, G35R, H51P/R, E54K, A60V, W77R/Stop, I84T, N98 K/T, G102R, Q118R/Stop, N123D and S124F/P.

Table: H51P/R

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Discussion: In the same study, S17A, P32L, W43L/R, H51P/R, and I84T/M of the pre-S1 region and W3R/Stop and S5A of the pre-S2 region were found in occult HBV infections.

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