In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: The nucleotide substitutions in the pre-S1 promoter region, particularly the G2765A mutation, reduce the L protein expression and regulate the biological situation of HBV and result in a low viral load and then less serious disease in chronic HBV infection.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Abstract: Among those with a viral load <=5.0 log IU/ml, patients with the G2765A substitution showed a significantly lower HBV viral load than those with the wild-type sequence.
Abstract: CONCLUSION: G2765A substitution in the pre-S1 promoter reduced the expression of L protein and resulted in a low viral load and less severe disease in chronic HBV infections.
Abstract: Furthermore, the G2765A substitution greatly reduced the L protein expression level of vector-produced virus particles.
Abstract: HepG2 cells transfected with the G2765A substitution vector showed reduced luciferase activity of the pre-S1 promoter,
HBV mutation literature information.
PMID: 
2020
Heliyon
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