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 HBV mutation literature information.


  Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
 PMID: 29479565       2018       Hepatoma research
Abstract: A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort.
Introduction: These mutations include A2159G, A2189C and G2203W at C gene, A799G, A987G and T1055A at P gene, and A1479T at X gene.


  Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
 PMID: 27727182       2016       International journal of molecular sciences
Abstract: A total of 10 mutations (including pre-S2 start codon mutation and pre-S deletion in pre-S gene, G1613A, C1653T, A1762T, and G1764A mutations in X gene, A2159G, A2189Y, G2203W, and C2288R mutations in C gene) showed an increased risk of HCC.
Abstract: In the validation study, pre-S deletion, C1653T, A1762T/G1764A


  Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
 PMID: 24788140       2014       PloS one
Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G, A2189C, and G2203W in the core gene are associated with HCC in Qidong.


  Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.
 PMID: 22014121       2011       BMC cancer
Discussion: A recent study from China revealed that 1613 and 1653 mutations were included in mutations frequently detected in HCC patients; however, core region mutants A2189C and G2203W were independent risk factors for HCC.


  Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.
 PMID: 20699378       2010       Cancer epidemiology, biomarkers & prevention
Abstract: CONCLUSIONS: These results implicate A2189C and G2203W as new predictive markers for HCC.
Abstract: In the validation study, A2159G, A2189C, and G2203W showed consistent associations with HCC by univariate analysis.
Abstract: Multivariate analysis showed that A2189C and G2203W were independent risk factors for HCC.



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