Method: A risk prediction model to classify the
HCC cases and controls was constructed according to the following steps: (1) Prediction factor selection: HBV genotype, the 11 independent
HCC-related mutations (
C1653T,
C1673T,
T1674C/G,
C1730G,
A1752G,
T1753C,
A1762T,
G1764A,
G1899A,
G1915A/C and
C1969T), the HLA SNPs (rs9272105 and rs9275319), the
HCC-related multiplicative interactions (rs9272105 with the HBV genotype,