Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Result: T1753A, A1761C, G1764T/A, C1766G/T, and C1773T mutations were detected in the BCP region.
Result: Of these, T1753A and A1761C mutations were detected in one sample (HB55); and G1764T/A, C1766G/T, and C1773T mutations were detected in two samples (HB35 and HB55).
Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients.
PMID: 34111075
2021
JPMA. The Journal of the Pakistan Medical Association
Abstract: A rare G1764T mutation was also detected in 6(12%) isolates.
Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia.
Result: Additional substitutions were observed in the upper regulatory region (URR) and BCP regions: patient 2C carried the HBV URR mutant G1728A and BCP mutant G1764T/C1766G, and HBV from patients 6C and 7C carried BCP T1768A and URR C1678T mutants, respectively.
Table: G1764T/C
Discussion: The G1764T/C1766G BCP double mutation is enriched among cirrhotic patients, and combined core mutations are more common in children with
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Abstract: Conclusions: Our results showed common mutations within HBsAg, occurring in immune epitopes, a high rate of G1896A mutations in the PC region, and a negative correlation between the emergence of A1762T/G1764A mutation and the G1764T/C1766G mutant in the BCP region.
Abstract: None of the strains with A1762T/G1764A mutation carried the G1764T/C1766G mutant.
Abstract: The PC and BCP mutations were G1896A (61.0%), PMID: 28859616
2017
BMC infectious diseases
Abstract: A1762T and G1764 T mutations and a double mutation (A1762T and G1764 T) in the BCP region were significantly more frequent in genotype C1 isolates (p < 0.001).
Result: T1753C, G1757A
Result: BCP/preC/core gene mutation: BCP mutations at T1753C, G1757A, A1762T, G1764 T and C1766G were analyzed and 30.4% (41/135) of all isolates including 78.4% (29/37) of the C1 isolates had at least one mutation.
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: A novel association of mutation C1773T with G1764T, C1766A, and G1757A was also found within a site already suggested to be a putative binding site for HNF-3.
Abstract: This novel association is proposed by us to be of importance for additional binding of HNH-2 to this site and is a better indicator of the emergence of the double mutation G1764T and C1766A than the G1757A mutation proposed previously.
Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.
Introduction: The basal core promoter (BCP) gene is a gene frequently changed in HBV as a double mutation (A1762T/G1764T) and has been found to be a codeterminant of HCC development and rapid disease progression in several populations.
Correlation between viral load of HBV in chronic hepatitis B patients and precore and Basal core promoter mutations.
Result: Seven of 8 genotype D or E isolates from HBeAg-positive patients had wild-type BCP/PC, and one (SDAC118) had G1764T.
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Result: HBV genotypes, HBeAg status, and frequencies of the BCP/PC/C mutations (T1753V, A1762T, G1764T, A1846T, G1899A, and C1913A/G) were included in the study.
Result: However there were no significant differences in previous reported hotspot mutations (T1753V, A1762T, G1764T, G1896A, and G1899A) between either CHB and ACLF-CHB patients or
HBV mutation literature information.
PMID: 
2022
PloS one
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