Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.
PMID: 31966550
2017
International journal of clinical and experimental pathology
Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Abstract: In addition, G1721A/A1775G/T1858C combined mutation was associated with higher viral load and lower age distribution.
Abstract: Several combined mutations were obviously highly distributed in children with chronic HBV genotype C infection, such as G1721A/A1775G/T1858C triple mutation; a novel combined mutation type, exclusively detected in children with chronic HBV genotype C infection.
Result: Combined mutation characteristics were also found in other hotspot mutation positions from genotype C sequences of children, such as G1721A (G1721A/A1775G
HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma.
Result: It was particularly interested to find that mutants A1630G and G1721A always appeared concurrently and that mutant A1762T constantly accompanied mutant G1764A.
Result: Of the double mutations A1630G/G1721A, the mutation G1721A does not lead to the alteration of HBx codon, and thus the double mutations affect only the codon 86 of the X protein (H86Y).
A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.
PMID: 19431214
2009
International journal of cancer
Abstract: Compared with the HBsAg-positive HCC controls, occult HBV-infected HCC patients had higher frequencies of M1I and Q2K in pre-S2 gene, G185R and S210N in surface gene, A36T and A44L in X gene, and G1721A in enhancer II gene, and had lower rates of pre-S deletions and A1762T/G1764A, PMID: 11472634
2001
BMC microbiology
Result: The following substitutions appeared to be linked to the genotype (although not all the isolates of a determined genotype necessarily showed the mutation): G to A 1721 (found in genotype F), G to A 1757 (D), C to T 1802 (F), G to T 1803 (F), A to T 1850 (D and F), and C to T 1858 (D and F).
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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