Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Abstract: Clinical prognosis-related genetic variations such as nucleotide mutation T1762/A1764 (27.93%), A2189C (12.85%), G1613A (8.94%), T1753C (8.38%), T53C (4.47%) T3098C (1.68%) and PreS deletion (2.23%) were detected in CD recombinants.
Table: G1613A
Discussion: Other mutations, such as T53C, G1613A, C1653T, T1753C, A2189C, T3098C and PreS deletions were also reported associated with clinical progress.
Discussion: The same result was also found in frequencies of mut
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Method: First, we classified 340 genotype C1 strains and 24 Cambodian isolates into 48 patterns by combinations of the following mutations pre-S deletion, G1613A, C1653T, T1753V, and A1762T/G1764A, Pre-C W28 stop codon, and P130 in the core region.
Result: Based on the presence or absence of the mutations of pre-S deletion, G1613A, C1653T, T1753V, A1762T/G1764A, Pre-C W28
Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.
Abstract: Moreover, the HBV genotype B4 isolates were found not only to be recombinants of genotype C, which results in a high cancer risk, but also to have other risk of HCC, pre-S deletions, the G1613A mutation, and X region insertions corresponding to the promoter.
Abstract: The promoter mutation G1613A was found in 13.6% of cases, and a 24 bp insertion from nt1673 in the X region was found in 6.3% of cases.
Result: Six out of the 44 isolates of HBV genotype B4 (13.6%) had a promoter mutation in G1613A (Fig 6).
Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Discussion: A1762T, G1764A, and T1753C/A mutations in the BCP region, and G1613A and C1653T mutations in the Enh II region were reported more frequent in HCC patients 27.
HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway.
Introduction: A1762T/G1764A (TA) mutations in the core promoter, which overlap with the HBx gene, are found commonly in HCC and are independent risk factors for the progression of HCC during chronic HBV infection.12 In vivo studies suggest that the TA mutant increases the replication capacity of HBV and suppresses HBeAg serum levels.13 A1762T/G1764A mutations are also predictors of postoperative survival in patients with HBV-related HCC.14 A1762T/T1764A<
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Abstract: A total of 10 mutations (including pre-S2 start codon mutation and pre-S deletion in pre-S gene, G1613A, C1653T, A1762T, and G1764A mutations in X gene, A2159G, A2189Y, G2203W, and C2288R mutations in C gene) showed an increased risk of HCC.
Result: Among these, 10 were point mutations, two (pre-S2 start codon mutation and pre-S deletion) were located in the
Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.
Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Method: The following mutation sites were also detected in the included studies: G1613A, C1653T, 1752G, T1754V, T1753V/A1762T/G1764A, T1758C, G1764A/C1766T/T1768A, T1770A, 1773 T, G1775A, C1799V, T1800C, T1803C, G1809T, A1814C, A1837G, A1846G, T1853C, PMID: 24344773
2014
Journal of viral hepatitis
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Abstract: In patients with >=6 mutations, the combination of [G1613A + C1653T + A1846T + G1896A] mutations was closely l
A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv