Discussion: Ma and Wang reported that eight mutations (P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R) are associated with diagnostic failure and mutations in the positions 120, 126, 129, 130, 133, 134, 137, 140, 143, 144, and 145 are recorded in escape variants hat evade vaccine or immunoglobulin therapy.
Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Discussion: Many studies (Protzer-Knolle et al.,; Beckebaum et al.,; Cheung et al.,) have demonstrated that M133T itself is frequently associated with occult HBV infection and is also often associated with some mutations in the 'a' determinant such as G130N, F134L, D144A, D144G, G145A, G145K, and G145R or failed hepatitis B immune globulin (HBIG) prophylaxis.
Analysis of HBsAg mutations in the 25 years after the implementation of the hepatitis B vaccination plan in China.
Abstract: HBV strains with internal stop codons of HBsAg (e.g., sC69*) and additional N-glycosylation (e.g., sG130N) mutations should be studied extensively to prevent them from becoming dominant circulating strains.
In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N, M133L, and M133T) or in relation to the patients with occult HBV infection (Y100C, C124R, C124Y, K141E, and D144A).
Molecular characterization of hepatitis B virus in blood donors in Botswana.
Discussion: Mutations T116N, T123N, G130N, and T131N + M133 T have been reported to reduce antigenicity and immunogenicity and rescue virion secretion in N146 mutants.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Result: Looking for VEMs, MRT showed only one patient highlighted the VEM G130N.
T
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Method: Mutations creating novel N-linked glycosylation, such as 112NG113, 114NT115, T115N, and G130N, were introduced to the 0.7mer construct by ClonExpress MultiS kit (Vazyme, China).
Result: The M133T mutation was most efficient at rescuing virion secretion of the G145R mutant, followed by G115N and G130N.
Result: To characterize their biological properties, we generated 0.7mer expression construct containing T115N, G130N, 112NG113 (insertion of the NG dipeptide between residues 112 and 113.
Discussion: In the current work we also performed limited study on four additional mutants creating novel N-linked glycosylation sites: T115N,
ViMRT
HBV mutation literature information.
PMID: 
2021
Infection and drug resistance
