ViMRT
}  
 
Home   
< Docs   

 HBV mutation literature information.


  The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro.
 PMID: 30472417       2019       Clinical microbiology and infection
Abstract: F30V also decreased the percentage of apoptotic cells compared with wild-type (14.8 +- 6.8% versus 19.1 +- 10.1%, p <0.01, without affecting cell-cycle progression) and increased the probability of HBx-Ser-31 being phosphorylated by PI3K-Akt kinase (known to promote anti-apoptotic activity).
Abstract: CONCLUSIONS: F30V was closely correlated with HBV-induced HCC in vivo, reduced HBV replicative efficiency by affecting HBx-binding to cccDNA and increased anti-apoptotic HBx activity in vitro.
Abstract: In vitro, F30V determined a 40% and 60% reduction in pgRNA and core-associated HBV-DNA compared with wild-type (p <0.05), in parallel with a significant decrease of



Browser Board

 Co-occurred Entities




   Filtrator