literature

HBV mutation literature information.

Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma.

PMID: 32504396 2020 Archives of virology

Abstract: The following mutations were significantly more frequent in HCC cases than in controls (p < 0.05): in the BCP/PC 1753C/G (22.5% vs. 0%), 1764A (69.4% vs. 38.1%), and T64C (51.5% vs. 20%) in the preS2, which results in a F22L substitution.

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Result: A11T, D14N, R16K, G19D, F22L, G30E, N33H, I42T, and P54Q/T were found; these mutations were not reported previously.

Discussion: Mutations of A11T, D14N, R16K, G19D, F22L, G30E, I42T, and P54Q/T were found in pre-S2.

Discussion: Other than F22L and P54T also found in the control

Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan.

PMID: 23865777 2013 BMC infectious diseases

Discussion: Six genotype E and three genotype D isolates had preS2F22L, which is a risk factor for HCC.

Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.

PMID: 24409056 2013 World journal of gastroenterology

Abstract: The preS2:F22L mutation was found in genotypes A and D.

A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

PMID: 22720022 2012 PloS one

Result: In the preS2 region, 5.5% of specimens had a point mutation in the start codon which changed the amino acid to I (3.3%), V (1.7%) or T (0.55%), and 5.3% had a mutation at F22L with either a single or dual point mutation at this site.

Discussion: Analysis of the preS region demonstrated that a total of 5% of specimens had preS deletions (primarily identified in high risk individuals), 5.5% contained amino acid mutations in the start codon of the preS2 and 5.3% had an F22L mutation in the preS2, all of which have been significantly associated with the development of HCC.

Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.

PMID: 20119580 2010 Journal of Korean medical science

Result: An F46S mutation was observed in Group P (n=2); a Q2K mutation in Groups P (n=1) and C (n=1); an A11T mutation in Groups P (n=2) and C (n=1); and an F22L mutation in Groups P (n=2) and C (n=2).

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