Result: Only F141V/L/I was found with a significantly higher rate in the HCC group (18.4% vs 9.6%, p = 0.08).
Result: The point-mutations with the rates of over 30% were T125S/N/P (30.8%), I150T (42.5%), and V158A (36%); from 10 to <30% of population were M120V/I (11.3%) and F141V/L/I (11.3%); and from 5 to <10% of population were Q121R/K (5.3%), T164I/D/S (6.1%), and F165S/L (5.7%).
Table: F141V/L
Discussion: Only F141V/L/I had the higher distributi
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Abstract: We also found that there are a total of 19 signature single nucleotide polymorphisms (SNPs), of which 2 and 17 nonsynonymous mutation types were specific to rt269L and rt269I, respectively: Of these, most are HBeAg negative infections (preC-W28*, X-V5M and V131I), lowered HBV DNA or virion production (C-I97F/L, rtM204I/V) or preexisting nucleot(s)ide analog resistance (NAr) (rtN139K/H, rtM204I/V and
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: The pre-S2 mutation F141L and the pre-S1 mutation W182*, leading to the premature termination of HBsAg, are reportedly associated with more severe HBV infection (Mun et al.,; Lee et al.,).
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Discussion: Additionally, the F141L mutation in the PreS region was not found in any of the HIV/HBV co-infected individuals, although this mutation was found to be significant among the liver cirrhosis patients compared to the chronic HBV cases with HBV mono-infection.
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Introduction: The two types of mutations related to clinical severity, the F141L preS2 mutation and W182* leading to premature termination in the HBV surface antigen (HBsAg), were recently noted in Korean chronic patients.
Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections.
Abstract: Application of MboII PRA to samples from 241 Korean patients with chronic liver diseases of different clinical stages confirmed that F141L mutants were significantly related to HCC, even in comparison to liver cirrhosis (HCC, 26.3% of patients, or 26/99; liver cirrhosis, 3.8% of patients, or 2/52; P = 0.001).
Abstract: By studying stable cell lines, we found that F141L-LHBs could induce cell cycle progression by downregulating the p53 and p21 pathways and upregulating CDK4 and cyclin A.
Abstract: Furthermore, we found that in a colony-forming assay, the colony-forming rates in cell lines expressing F141L- PMID: 22012717
2011
Journal of medical virology
Abstract: One strain carried the F141L mutation, associated recently with increased risk of hepatocellular carcinoma.
HBV mutation literature information.
PMID: 
2022
PloS one
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