Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Discussion: In addition to the three IEMs identified, several surface protein mutations were identified (sP56Q, sT57I, sN59S, sP62L, sI110L, sS140T, sE164G, sS207N, and sL216*), which have also been reported in previous studies (Mello et al.,; Lin et al.,; Munshi et al.,; Qin and Liao,).
A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants.
Result: We found that these mutations, either alone or in combination of doubles, do not affect Lenvervimab binding with the exceptions of E164A/D/G/V (Fig 6).
Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.
PMID: 32997000
2020
Memorias do Instituto Oswaldo Cruz
Table: E164G
Discussion: Interestingly, amino acid substitution E164G was also observed in a study conducted among Nigerian blood donor samples.
Discussion: With regards to additional analysis for sample BSM1498 belonging to genotype E, amino acid substitution E164G was observed within the MHR.
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Discussion: reported that the sE164G substitution, driven by vaccine escape and outside of the 'a' determinant, was also associated with occult HBV infection.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: Outside of the 'a' determinant, common mutations occurred at residues 164 (sE164G in 5/46 and sE164A in 1/46), 110 (sI110L in 5/46) and 184 (sA184V in 2/46).
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Discussion: Additional mutation outside the MHL region was also observed including the E164G mutation, which was earlier reported by another study on chronic HBV carriers.