Discussion: However, in spite of their prevalence, our data showed that
E80Q/D,
E113D/Q,
S181P/R and
Q182K/*Stop variations were not statistically significantly different among the groups.
Discussion: There were some variations such as
E77Q,
E113Q,
S181P/H and
Q182K/*Stop outside of the epitope regions which have previously been reported to accumulate with disease progression.