Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, PMID: 30943997
2019
Virology journal
Abstract: Sequencing revealed multiple substitutions in preS1, preS2, and S regions for one panel including a rare D144N substitution associated with vaccine breakthrough that emerged with increasing frequency as the breakthrough infection developed.
Result: The D144N substitution within the immunodominant 'a' determinant occurred as a mixture with wild-type.
Figure: The bars above the 6272 graph show the percentage of codons with the HBsAg D144N mutation.
Discussion: Hydrophilicity analysis of the second loop of the HBsAg major hydrophilic region by the Hopp & Woods method indicated that a mutation to asparagine at amino acid 144 would result in a redu
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Result: However, 60% of our strains had the S143T polymorphic mutation followed by G145K and K141R (for 2 patients) and M133I and D144N (for one patient) (Fig 4, Table 4).
Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.
Result: In addition, the other six mutations types (P127T, A128V, G130E, T131P, M133I and D144N) were not yet identified as VEMs, and D144N was a newly identified mutation (Table 3).
Table: D144N
Discussion: Additionally, a small amount of P127T, A128V, G130E, T131P/N, M133T/I, F134L and D144N mutations was observed in our study, including the less frequent T131N/M133T doubl
Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
HBV mutation literature information.
PMID: 
2021
Journal of viral hepatitis
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